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Lagolax

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OTC

20 double sachets 6.5 g of Macrogol 3350 per sachet + electrolytes

Composition and dosage

One sachet contains:

Macrogol (3350) 6.5625 g;

Sodium chloride 0.1755 g;

Sodium bicarbonate 0.0895 g;

Potassium chloride 0.023 g

Excipients: Silicon dioxide, orange flavor, Sodium saccharin.

Lagolax is a powder in sachets for the preparation of an Lagolax is a powder in sachets for the preparation of an oral solution.

The box contains 40 disposable sachets of 6.94 g of powder.

A full dose corresponds to 2 sachets.

The dosage is as follows:

Adults, elderly and children over 12 years: Take a full dose - 2 sachets (13.88 g) 1 to 3 times daily.

In case of prolonged administration, the dose can be reduced to 2-4 sachets per day.

Children 7 to 11 years old: one sachet (6.94 g) twice daily.

Children 3 to 6 years old: one sachet (6.94 g) once a day.

DO NOT ADMINISTER LAGOLAX TO CHILDREN UNDER 3 YEARS OF AGE.

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a feeling of lightness

Constipation

Origines

Constipation is a common digestive disorder that affects many people at different times in their lives. Here is a summary of the main causes and characteristics of constipation:

Definition

Constipation is characterised by bowel movements that are less frequent than normal (less than three times a week), difficulty passing stools or hard, dry stools. It may be occasional or chronic.

Main causes

  • Insufficient fibre in the diet: Fibre helps to build stool volume and make it easier to pass. A diet low in fibre can therefore lead to constipation.

  • Lack of fluids: Not drinking enough water can make stools hard and difficult to pass.

  • Lack of exercise: Physical activity helps stimulate intestinal activity. Inactivity can therefore contribute to constipation.

  • Ignoring the need to go to the toilet: Regularly holding off the urge to have a bowel movement can make constipation more likely.

  • Changes in routine or lifestyle: For example, travel, changes in working hours, or other disruptions can affect the regular functioning of the intestines.

  • Medications: Certain medications, particularly opioid analgesics, certain anticonvulsants and iron supplements, can cause or aggravate constipation.

  • Medical conditions: Conditions such as diabetes, hypothyroidism or neurological disorders can affect bowel function.

  • Stress and mental health: Stress and psychological problems can also influence digestion and intestinal activity.

Benefits

Macrogol, also known as polyethylene glycol (PEG), is a type of osmotic laxative frequently used to treat constipation. It is often combined with electrolytes to help maintain the body's electrolyte balance during treatment. Here's an overview of the main benefits of this combination in the treatment of constipation:

1. Effective in treating constipation

Macrogol draws water into the stool, making it softer and easier to pass. This can help relieve constipation effectively, including chronic constipation.

2. Preventing dehydration

The addition of electrolytes (sodium, potassium, chloride, bicarbonate) helps to prevent electrolyte imbalances that may occur as a result of increased water in the intestines, which is particularly important when using osmotic laxatives such as macrogol.

3. Safety in use

Macrogol is generally considered safe for most people, including long-term use under medical supervision. It is not addictive and does not alter normal intestinal function.

4. Ease of use

The treatment is often available as a powder to be dissolved in water, making it easy to administer and the dose can be adjusted to suit individual needs.

5. Use in various patient groups

It can be used in adults, including the elderly, and is often considered an option for children in cases of chronic constipation, under medical supervision.

6. Few side effects

Macrogol with electrolytes generally has few side effects. The most common are mild gastrointestinal symptoms such as bloating, gas or abdominal cramps.

7. Versatility

It can be used for intestinal preparation prior to certain medical or surgical procedures, in addition to its use for constipation.

However, although macrogol is generally well tolerated, it is important to use it in accordance with the recommendations of a healthcare professional to avoid potential side effects and ensure that it is appropriate for the patient's specific situation.

Mechanism

Macrogol (polyethylene glycol) acts as an osmotic laxative, which means it works by retaining water in the stools. Here's a more detailed, step-by-step explanation of its mechanism of action:

  • Water absorption: Macrogol is a large molecule that is not absorbed by the intestine. When ingested, it passes through the digestive system.

  • Osmosis: As macrogol cannot be absorbed, it attracts and retains water in the colon through a process called osmosis. This increases the volume of water in the intestine.

  • Increased stool volume: The water retained by macrogol increases the volume and water content of stools, making them softer and bulkier.

  • Stimulation of peristalsis: The increased volume of stool stimulates the intestinal muscles to contract (peristalsis), which helps push the stool outwards.

  • ÉEasier emptying: softer, bulkier stools are easier to pass, which relieves constipation.

Side effects

  1. Occasionally, gastrointestinal problems may appear, with borborygma, abdominal pain, nausea and mild diarrhoea (especially at the beginning).

  2. Rarely, hypersensitivity reactions (rush, urticaria) may occur. Consult your doctor or pharmacist if you experience any side effects, even if they are not mentioned. If the symptoms persist, consult your doctor. If you forget to take a dose, do not take a double dose, but wait and take the next one.

But even when the tolerance of a product is considered to be excellent, it is advisable to seek the advice of a health professional, especially if the condition is recurrent or arises in specific situations.

Conclusion

Lagolax is a good preparation for treating chronic constipation. It has been well documented in numerous studies.

The medicine should be used in accordance with the recommendations given in the package leaflet, at the dosages defined according to age.

 

Health professionals are well acquainted with macrogol and their advice will be invaluable if you have any doubts or are unsure of its effectiveness.

food

sedentaryism

by Malek Ben Mansour

08.05.2024

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Generalities

Junk food and a sedentary lifestyle are two major risk factors for many chronic diseases. Here are some of the significant negative effects associated with these habits:

  • Obesity and weight problems: Junk food is often high in calories, fat and sugar, but low in essential nutrients. Regular consumption of these foods, combined with a lack of physical activity, can lead to excessive weight gain and obesity.

  • Cardiovascular disease: Diets high in saturated fat, sugar and salt can increase the risk of developing cardiovascular disease. This includes hypertension, atherosclerosis, heart attacks and strokes. A sedentary lifestyle can also contribute to these problems by reducing the efficiency of the heart and blood circulation.

  • Type 2 diabetes: An unbalanced diet combined with excess weight and lack of exercise can increase the risk of developing type 2 diabetes. This condition is characterised by insulin resistance, which makes it difficult for the body to regulate blood glucose.

  • Joint and musculoskeletal problems: Obesity increases the load on joints, particularly the knees and hips, which can accelerate wear and tear and increase the risk of arthritis. Lack of exercise can also weaken muscles and bones, contributing to a reduction in bone density and muscle strength.

  • Psychological effects: Junk food and lack of physical activity can also have negative effects on mental health. They are often associated with an increased risk of depression, anxiety and low self-esteem.

  • Increased risk of certain cancers: A poor diet and a sedentary lifestyle are linked to an increased risk of certain types of cancer, such as colorectal cancer and post-menopausal breast cancer.

Effects on digestion

  • Digestive disorders: Junk food, often high in fat and low in fibre, can cause digestive problems such as constipation. Fibre is essential for regular bowel movements and preventing constipation.

  • Gastroesophageal reflux disease (GERD) : A diet rich in fatty and spicy foods can increase the risk of gastro-oesophageal reflux disease (GERD), a condition where stomach acid backs up into the oesophagus, causing heartburn and other symptoms.

  • Dysbiose intestinale: An unbalanced diet can upset the balance of bacteria in the intestinal microbiome, leading to dysbiosis. This condition can affect digestion, nutrient absorption and even the immune system.

  • Increased inflammation : Diets high in refined sugars and trans fats can contribute to systemic inflammation, which can exacerbate gastrointestinal problems such as inflammatory bowel disease.

  • Abdominal fat and its impact on the liver: Excessive consumption of junk food can lead to an accumulation of fat around the abdomen and in the liver, causing non-alcoholic fatty liver disease, which affects liver function and can disrupt digestion and metabolism.

 

Regular physical activity helps to stimulate digestion and can improve intestinal transit, thereby reducing some of these negative effects. It is therefore important to combine a healthy diet with an adequate level of physical exercise to support optimal digestion.

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